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Hydroquinone is a prescription-strength bleaching agent that inhibits melanin production but carries risks including skin irritation, paradoxical darkening with prolonged use, and ochronosis with very long-term use

Early-phase trials demonstrate enhanced ORR and manageable toxicity with 177Lu-PSMA-617 plus PD-1 inhibitors in mCRPC, including a phase I study where pembrolizumab combination therapy achieved superior activity and reduced adverse events compared to monotherapy (Prasad et al., 2021

The inability to absorb vitamin B12 fatigue glossitis, which causes changes in the size, color, and texture of the tongue shortness of breath a loss of appetite and weight loss cognitive decline imbalance numbness heart palpitations diarrhea depression mood changes Pernicious anemia is an autoimmune disorder Researchers do not know the exact causes of the disorder

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