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Positive outcomes were reported in both studies, with improvement in motor function and constipation and increase in plasma levodopa levels after DRIF [101], and increase in stool frequency and weight but no effect on colonic transit time after psyllium treatment [102]

Solhi H, Ghahremani R, Kazemifar AM, Hoseini Yazdi Z

Asian Pac J Cancer Prev 18:39 Farjadian F, Roointan A, Mohammadi-Samani S, Hosseini M (2019) Mesoporous silica nanoparticles: synthesis, pharmaceutical applications, biodistribution, and biosafety assessment

Perform gentle facial expressions like raising brows, smiling, and frowning during the first few hours to help the product bind evenly (no conclusive clinical mandate, but many injectors suggest it)