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Pharmacologic anti-inflammatory therapy is reserved for selected patients and should be considered only by a qualified clinician who can weigh cardiovascular benefit against infection, gastrointestinal, kidney, liver, bleeding, and medication-interaction risks
These injections are often used to target stubborn fat, promote its breakdown for energy, and support overall weight loss efforts when combined with a healthy diet and exercise
Zonal organization: Articular cartilage has superficial zone (tangential collagen orientation, highest cell density), middle zone (random collagen orientation, largest proteoglycans), deep zone (perpendicular collagen orientation, calcified interface with bone), and tidemark (boundary between calcified and uncalcified cartilage)
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