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The combination is appealing because using a GHRH analogue such as CJC-1295 with a secretagogue like Ipamorelin potentially allows lower frequency dosing, better control over GH peaks/troughs, and possibly fewer side effects from GH overshoot or non-GH hormone activation

Emerg Med Internat, 2020 (2020), pp

For most other applications, ipamorelins cleaner profile is preferred, which is why ipamorelin remains the default choice in most sermorelin vs CJC-1295 vs ipamorelin protocols