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In the acute phase of ischemia, which is characterized by anoxic depolarization and a massive increase in [Ca 2+ ] i mediated by both Ca 2+ influx and Ca 2+ -induced Ca 2+ release from intracellular stores, the vesicular release from presynaptic terminals further adds to the glutamate elevation

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Once reconstituted with bacteriostatic water, the solution should be stored at 28C and used within 4 weeks to maintain peptide integrity