Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC, Spertus JA, Costa F: Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific statement
In some embodiments, the otic formulation or composition comprises between about 0.01% to about 50% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof
It can take weeks or months to develop and causes 10-15% of acute liver failure in the U.S
NHPN-1010 is a fixed combination product consisting of two antioxidants, i.e., N-acetylcysteine (NAC, a glutathione prodrug) and 2,4-disulfophenyl-N-tert-butylnitrone (HPN-07, a nitrone compound)