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Blueberries anthocyanins can decrease A2E-epoxidation by extinguishing singlet oxygen and act as RPE cells barrier from A2E cytotoxicity [240]

Fadillioglu E, Kaya B, Uz E, Emre MH, nal S

The core direction of future research should focus on directly verifying the causal relationship between local joint ferroptosis and gut microbiota dysbiosis through germ-free OA mouse models, fecal microbiota transplantation experiments, or conditional knockout models of key genes for chondrocyte-specific ferroptosis (such as GPX4 and ACSL4)

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