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This drug is short acting and the effects last less than 24 hours, but can be longer in dogs with kidney or liver problems

Dragovich T, Mendelson D, Kurtin S, Richardson K, Von Hoff D, Hoos A (2006) A Phase 2 trial of the liposomal DACH platinum L-NDDP in patients with therapy-refractory advanced colorectal cancer

EGFR activation leads to induction of MAPK signaling (via p38, ERK1/2) and the activation of c-Fos (Naglik et al., 2019), ultimately triggering the production of inflammatory mediators such as G-CSF and GM-CSF (Nikou et al., 2022), and the activation of the NLRP3 inflammasome leads to the release of IL-1 (Rogiers et al., 2019)

The green curve shows the rescue of the male by the protocol described above, starting 10 h after ingestion