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As HNF4 suppresses EMT 31,34,35,36 , the shared metabolic changes between above two cell types suggest that defective SAA metabolism driven by HNF4 deficiency could be a feature of EMT, which is commonly associated with tumor metastasis and drug resistance 53

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doi: 10.1016/j.pbb.2014.05.006 192 ShibataKMakinoIShibaguchiHNiwaMKatsuragiTFurukawaT