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In animal models it has been associated with tendon, ligament, muscle and gut healing , angiogenesis and cytoprotection effects reported preclinically, not confirmed in controlled human trials

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Along this line, altered expression or function of these ion channels and receptors has been correlated with impaired receptivity, implantation failure and linked to several endometrial pathologies, making them interesting targets for diagnostic and therapeutic interventions [39, 45, 46]