Moreover, caspase-8 was found to antagonize necroptosis, as evidenced by accelerated necroptosis of erythrocytes in response to caspase-8 inhibition [198]
10.1177/0960327118774902 10 AndradeR
a chronic respiratory disease that constricts the air pathways and induces wheezing, chest pain or dry cough
Although both the PERK-eIF2-ATF4 and ATF6 branches of the UPR have been implicated in the regulation of ferroptosis with diverse cellular context and inducing agents 48,49,50,51,52,53,54,55,56,57,58,59,60 , we found that when the expression of the key transcription factors of the three UPR branches, XBP1, ATF4 and ATF6 was inhibited individually in MDA-MB-231 cells, ferroptosis induction by erastin treatment was not affected (Fig