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Keywords: disulphide-bond formation, endoplasmic reticulum, glutathione, oxidative stress, reactive oxygen species Introduction Glutathione (GSH) is a tripeptide (L--glutamyl-L-cysteinyl-glycine) that is synthesized in the cytosol from the precursor amino acids glutamate, cysteine and glycine

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Under glucose starvation conditions, damage to the pentose phosphate pathway can lead to a decrease in its metabolic product NADPH, resulting in a reduction in NADPH electron donors that prevent cystine from being converted to cysteine