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Microglia express CRH receptors, and activation of microglia by CRH from brain cells cause the release of neurotoxic inflammatory mediators in mental disorders (Kritas et al., 2014a)

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On the other hand, in another study of PSD, a high dose of caffeine impairs memory and leads to an anxiogenic and depressive-like behavior in the hole board and elevated plus maze tests, and social interaction and locomotor activity, respectively, also increased pro-inflammatory cytokines such as TNF-alpha and IL-6 [37]

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