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Adverse-event tables capture what trial staff asked about or participants reported

Cardiac-specific elision of Fth1 (encoding ferritin heavy chain) causes iron dysregulation and increased oxidative stress in the heart, leading to increased sensitivity to ferroptosis induced by iron overload [76]

In elderly human monocyte-derived macrophages (MDMs), increased oxygen consumption and decreased activity of mitochondrial complexes I and II have been observed, along with reduced NAD + synthesis, which may explain the overall decline in immune function with aging [226]

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