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Parallel studies in OVCAR5 expressing R175H showed that induction of p53 did not enhance the synergy between APR-246 and ML-210 (Supplementary Fig

Retatrutide (LY3437943), developed by Eli Lilly, is a first-in-class triple GIP/GLP-1/glucagon receptor agonist

injection of 50 mg/kg sodium pentobarbital (Sigma), and thoracic aorta was carefully dissected and maintained at 37 C in Krebs solution containing 118.2 mM NaCl, 4.7 mM KCl, 1.2 mM MgSO 4 , 25 mM NaHCO 3 , 1.2 mM KH 2 PO 4 , 1.9 mM CaCl 2 and 11.7 mM dextrose (pH 7.4, 95% O 2 , 5% CO 2 )