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In addition, previous studies have also suggested that increased levels of miR-4474 and miR-4717 in CRC tissues with positive infection of Fusobacterium nucleatum lead to decreases in the expression of CREB-binding protein (CBP), thereby promoting the progression of CRC (141)

However, no significant changes in gut microbiota composition were detected ( 3.4.4.2 Prebiotics In a male rat model of PTSD-like symptoms induced via amygdala hyperactivation (a key pathophysiological mechanism of PTSD)3 weeks of treatment with the prebiotic GOS restored microbial homeostasis by enriching beneficial Bifidobacterium animalis and Limosilactobacillus reuteri , while eliminating harmful Enterococcus casseliflavus (Ruciski et al., 2025)