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Interestingly, treatment withdrawal did not completely restore the mRNA transcripts, and a similar effect was observed for vitamin D metabolism genes and genes associated with NAFLD which was persistently higher, suggesting the epigenetic association between GSH deficiency and vitamin D metabolism genes

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Emerging roles of cystathionine beta-synthase in various forms of cancer

A highly oxidized environment is essential for this process, which is maintained by a series of enzymatic components especially endoplasmic reticulum oxidoreductase 1 (ERO1) and protein disulfide isomerase (PDI) [46]