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APAP metabolism can be divided in three phases ( Figure 1 ): (1) The major bulk of APAP (8590%) is metabolized by UDP-glucuronosyl transferases (UGT) and sulfotransferases (SULT), with conversion to glucuronidated (5660%) and sulfated (2830%) non-toxic metabolites, which are excreted through the urine ( (2) A minor fraction of APAP (25%) is directly excreted in the urine

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AOD-9604 works by activating specific receptors that influence lipolysisthe breakdown of fat and inhibit lipogenesis, the creation of fat cells