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Finally, a low LVEF (OR = 0.953, 95% CI 0.9200.987, p = 0.008), exposure to alcohol (OR = 3.239, 95% CI 1.1968.774, p = 0.021), and smoking (OR = 3.694, 95% CI 1.3969.775, p = 0.008) were associated with the formation of an LV-LGE (Table 3)

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Underlying mechanisms for such outcomes occur through multi-faceted interaction among flavoring agents and respiratory epithelium, and isolated compounds such as cinnamaldehyde and diacetyl are recognized for cytotoxic and inflammatory actions 8