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NAPDH Oxidase converts oxygen to Super Oxide (O 2 ) mainly in neutrophils Myeloperoxidase (MPO) converts peroxide (H2O2) into Hydrochloric Acid (HOCl) mainly in neutrophils Fenton Reaction generates Hydroxide (OH-) from peroxide (H2O2) using iron Superoxide Dismutase (SOD) converts Super Oxide (O 2 ) to peroxide (H2O2) Glutathione convert Hydroxide (OH-) to water Catalase converts Peroxide (H2O2) to water We will see in the immunology section that that a defect in NADPH Oxidase causes Chronic Granulomatous disease
The tissue was embedded with 100% Polybed 812 mixture (without DMP-30) overnight in the hood, followed by 100% Polybed 812 mixture with 1.5% DMP-30, in molds, and into an oven at 60 C for 24 h
Our results show that while on day 7, the signs of inflammation and formation of crusty scab were clearly observed in all the wound tissues treated with the different nanofibrous dressings, these signs almost vanished on day 14 in the tissues treated with the semi or full drug-loaded core-shell nanofibers
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