In addition, brain-region specificity may influence antioxidant readouts, such as cortex, hippocampus, striatum, and cerebellum show distinct redox and metabolic profiles in ASD models
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For example, VIR-2218, a GalNAc-siRNA conjugate that targets HBV, uses enhanced stability chemistry plus technology to stabilize the siRNA in vivo and reduce off-target effects
The authors of both studies attributed the results to an improvement in the intestinal absorption of fluids and electrolytes and possibly increased skeletal muscle uptake causing greater neuromuscular performance, besides a possible gluconeogenic effect of alanine, sparing muscle glycogen, and retarding fatigue [144, 146]