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In addition, for non-dyslipidemic patients the antioxidant enzyme deficiencies were: 33% for atrial flutter, 31% for various combined arrhythmias, 30% for sinus tachycardia, 29% for sinus bradycardia, 28% for ventricular extrasystole, 27% for atrial fibrillation and atrial extrasystole, and 18% for paroxysmal supraventricular tachycardia
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Over-supplementation could potentially disrupt the delicate oxidative balance in the liver, leading to adverse effects rather than the desired protective benefits
J Cell Biochem 104:13561363 Kawanishi N, Sugimoto T, Shibata J, Nakamura K, Masutani K, Ikuta M, Hirai H (2006) Structure-based drug design of a highly potent CDK1, 2, 4, 6 inhibitor with novel macrocyclic quinoxalin-2-one structure
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