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The CagriSema combination represents a paradigm shift in obesity pharmacotherapy, producing mean weight loss (22.7%) that approaches bariatric surgery efficacy without invasive procedures

cGMP, in turn, activates cGMP-dependent protein kinase resulting in membrane hyperpolarization and subsequent vasodilatation

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Hennes A, Devroe J, De Clercq K, Ciprietti M, Held K, Luyten K, Van Ranst N, Maenhoudt N, Peeraer K, Vankelecom H, Voets T, Vriens J (2023) Protease secretions by the invading blastocyst induce calcium oscillations in endometrial epithelial cells via the protease-activated receptor 2