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For gene ontology (GO) analysis, the Seurats FindMarkers output for the specified groups was used to plot gene ontology terms with the barcodeplot functions from limma 131

In four randomized controlled trials (RCT) conducted in patients with obesity without T2D 15,16,17,18 , liraglutide 3.0 mg was compared to placebo as an adjunct to lifestyle optimization over 56 weeks, with the exception of the 3-year extension of the SCALE Obesity and Prediabetes study

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