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Second, its interaction with amino acid metabolism: intermediates of glucose metabolism and the tricarboxylic acid (TCA) cycle provide carbon skeletons for amino acid synthesis and transformation, while also modulating NADH levels, thereby influencing GSH production (103)

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Another recurring limitation emerges on antioxidant-based interventions in ASD, constrained by a fundamental methodological gap: most clinical studies report behavioral or functional improvements without directly measuring oxidative-stress biomarkers