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109,110 GRs are expressesd at higher levels and particularly concentrated in the pituitary and hypothalamus, as well as a variety of regions of the limbic system (including the amygdala, hippocampus, and PFC), which are important for cognitive and psychological functions

Studies using the Caco-2 Brush Border Expressing clone 1 cell line (Caco-2 BBe1) model demonstrate that glycosylated flavonoids are primarily absorbed via Sodium-dependent glucose transporter 1- and Glucose transporter 2-mediated active transport, whereas aglycones are mainly taken up by passive diffusion (Zhang et al., 2020)