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Simultaneously, both BAPTA-AM and 2-APB treatment also significantly inhibited the upregulation of Bax and cle-Caspase3 induced by H 2 O 2 , and induced the upregulation of Bcl-2 in Prx II-knockdown HaCaT cells, the Bax/Bcl-2 and cle-Cas3/pro-Cas3 ratio were found to be significantly decreased (Fig

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Human samples Human AD brain samples were kindly provided by Dr