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Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide

Applying heat to the abdomen is a popular home remedy for digestive discomfort, including constipation

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The disease is caused by a mutation in the ATP7B gene, which codes for a protein that facilitates the incorporation of copper into proteins (such as ceruloplasmin) and also the transportation of copper into vesicles that allow it to be secreted in bile.1 The critical effect of a mutation in ATP7B is diminished copper secretion into bile, which leads to excess copper accumulation in the hepatocyte