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While this unidirectional behavior effectively destroys cell metabolism for tumor suppression, it poses challenges because of the absence of coupling between the intracellular nanostructures and endogenous feedback mechanisms, thereby hindering their translation to scenarios requiring sustained cellular viability and precise, nondestructive function modulation, including probiotic interventions 46 , programmable cell-based therapeutics 47 and engineered living materials 48

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however, it seems that an increased risk of HF does not increase the risk of death or cardiovascular events following HF

The main challenge with oral glutathione supplements is their poor bioavailability