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By increasing cysteine levels, NAC effectively helps boost glutathione levels, particularly in individuals who may not be producing enough due to stress, illness, or age-related decline

Subsequent research using intermittent protocols achieved comparable neuroplastic outcomes with less total compound exposure and presumably lower risk of tolerance development

This supports a model in which CHAC1-mediated GSH depletion destabilizes NRF2 and reduces cystine import, allowing iron-dependent lipid peroxides to accumulate and trigger ferroptosis

A reduction in total choline in long COVID is of interest in the context of the recently reported association between blood clots and brain fog, and earlier animal studies showing that choline might prevent intravascular coagulation