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This is an immune response (chiefly against bacterial invasion) that is mediated by B cells and involves the transformation of B cells into plasma cells that produce and secrete antibodies to a specific antigen

These include vitamin E, pioglitazone (PPAR agonist), obeticholic acid (farensoid X receptor agonist), cenicriviroc (CCR2/CCR5 antagonist), selonsertib (apoptosis signal-regulating kinase 1 inhibitor), and liraglutide (glucagon-like peptide 1 analogue) [136,137,138,139,140,141]

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Resistant cells often exhibit increased invasiveness, motility, and tumorigenic potential, along with metabolic reprogramming