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The appearance of mild-yellowish, mosaic symptoms was associated with a dramatic, 20-fold induction of defense-related genes like PR-1, chitinase and GST (Niehl et al., Potato virus Y (PVY) strains, the aggressive PVY NTN and the mild PVY N (Kogovsek et al., NTN -inoculated leaves displayed chlorotic and/or necrotic ringspot type lesions, while PVY N caused a mild chlorotic ringspot

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GHRP-6 was historically significant as the compound that helped identify the growth hormone secretagogue receptor (later identified as the ghrelin receptor)