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Mechanical and chemical stress can lead to an increase in the production of oxygen free radicals, resulting in oxidative damage to tissue (Pizzino et al., 2017)

Long-term treatment of glucocorticoids is associated with oxidative brain damage in primates, which has been demonstrated (113)

In addition, the neuroanatomy and the mechanism as to why cZi or Rsprl in PSA might be superior targets to VIM for neuromodulation in tremor will need to be explored