What they found: In normal obese mice: AOD-9604 reduced body fat by 21 % vs placebo, hGH by 24 % The AOD-9604 effect was fully dependent on the 3-adrenergic receptor , in knock-out mice no effect The hGH effect was partly independent of 3-AR , in knock-out mice there was still ~10 % fat reduction AOD-9604 did not raise IGF-1 (control level), whereas hGH raised IGF-1 by 80 % No changes in growth, organ weights (except adipose tissue), fasting insulin Why it matters: The study provided the mechanistic basis for AOD-9604 and confirmed the key business hypothesis: it is possible to separate the lipolytic effect of GH from its growth effect
216 Because of this evidence, the International Lipid Expert Panel recommended red yeast rices use in those whose LDL target has not been reached due to statin intolerance
[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Gojkovic S., Krezic I., Vranes H., Zizek H., Drmic D., Pavlov K.H., Petrovic A., Batelja L., Milavic M., Sikiric S., et al
Inflammatory signaling research: Evaluation of biological pathway interactions
