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An increased incidence of micronuclei was observed after one intraperitoneal dose of 100 mg/kg body weight in mice (Lyarskii et al., 1983) and after 4 h of vapour exposure of rats to a concentration of 90 mg/m 3 (Embree & Hine, 1975)

In summary, our in-silico trajectory analysis suggests a developmental lineage of human secretory cells, driven by sequentially activated TFs, which transitions through functional intermediates (club cells) to culminate in a multi-functional mucus secretory cell 29,30,31,32 , although all cells in this lineage need not reach this mucus secretory endpoint, depending on internal or external differentiation cues

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