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Because of spatial constraints, genes must engage in a complex unfolding process to become accessible to the transcriptional machinery, which is triggered through posttranslational modifications at the N-terminal tails of core histones

[DOI] [PMC free article] [PubMed] [Google Scholar] 275.Torres M.A., Dangl J.L., Jones J.D.G

Individuals with the homozygous variant TT genotype in MTHFR appear to have reduced MTHFR enzyme activity and thus impaired folate metabolism and OCM

Specifically, IFN- activates macrophages, neutrophils, and dendritic cells (DC) to destroy intracellular pathogens by producing reactive oxygen species (ROS), reactive nitrogen species, and antimicrobial peptides