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evaluated the efficacy of a combination product (containing acetaminophen 500 mg, aspirin 500 mg, and caffeine 130 mg) versus sumatriptan (50 mg)

The flow rate was maintained at 0.5 ml min 1 , and the gradient was as follows: 0.0 min 100% of MPB, 0.011.5 min 70% of MPB, 11.512.5 min 60% of MPB and 12.515.5 min 100% of MPB