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Epigenome-wide association study (EWAS) in children similarly demonstrates that high-UPF diets are linked to DNA methylation changes in several genes relevant to neurodevelopmental disorders and behavioral regulation (151)

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In clinical trials, tirzepatide demonstrated reductions in hemoglobin A1c of up to 2.5% and weight loss of approximately 15-21% of body weight at higher doses after 72 weeks of treatment, with results varying by dose and patient population