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Thyroid hormone regulation of hepatic genes in vivo detected by complementary DNA microarray

All cell lines were confirmed to be free of mycoplasma, viral infections and contaminations with other cell lines, based on multiplex polymerase chain reaction (PCR) and single nucleaotide polymorphism (SNP) profiling

A small randomized study (5) with N=60 patients where melatonin was orally administrated (3mg/day) from day 3-5 until hCG administration (oocyte collection) showed: a higher number of total oocytes (11.5 vs 6.9) higher number of mature oocyte (9% vs 4.4%) a higher rate of embryos transferred (69.3% vs 44.8%) These results were confirmed in another independent trial (6)

These include subgroups with hyperactive mitochondrial respiration, partial disfunction, or classical mitochondrial disease patterns, each potentially associated with different clinical features such as neurodevelopmental regression or immune malfunction (Frye et al., 2024)