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With overdose it can produce muscarinic & nicotinic symptoms SLUDE Muscarinic : nausea, vomiting, diarrhea, abdominal cramps, increased peristalsis, increased salivation, increased bronchial secretions, miosis and diaphoresis Nicotinic side effects are comprised chiefly of muscle cramps, fasiculation and weakness Overdosage may result in cholinergic crisis, a state characterized by increasing muscle weakness which, through involvement of the muscles of respiration, may lead to death Pharmacokinetics for MG: Pyridostigmine is available in 3 dosage forms for MG: 1) oral solution

This leaves late-comers Roche, AstraZeneca, Novartis, Pfizer, Amgen and smaller player Viking with a fraction of the market, approximately $20B

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When clinically appropriate, they may be prescribed for eligible patients through licensed 503A compounding pharmacies based on an individual prescription and provider evaluation