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In a controlled trial involving healthy older women, twice-daily consumption of a protein beverage enriched with ~4 g of leucine elicited significantly greater increases in both acute and integrated myofibrillar protein synthesis compared with an isonitrogenous mixed-protein beverage containing lower leucine content
Side Effects and Safety# Epitalon Safety Profile# Preclinical record: No significant adverse effects across decades of animal studies Injection site effects: Mild redness and transient discomfort at injection sites Cancer concern: Telomerase activation theoretically risks promoting pre-cancerous cells, though Epitalon studies showed reduced rather than increased tumor incidence Limitation: Safety data predominantly from a single research group without large-scale, independent safety assessments NAD+ Safety Profile# Human trial data: NMN (250-1200 mg/day) and NR (300-2000 mg/day) have shown favorable safety in multiple human studies lasting weeks to months Common effects: Mild GI symptoms (nausea, bloating) at higher doses
Nevertheless, we selected the controls so that about one-third of them had distress or adjustment symptoms as a result of lockdowns and social isolation to account for their confounding effects, which are also seen in Long COVID patients
