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Therefore, further investigation is warranted to elucidate the regulatory role of E2 on OSAHS-induced cellular autophagy across various tissues and organs, particularly emphasizing the mechanisms governing the interaction between E2 and HIF-1

doi: 10.1053/j.gastro.2017.05.003, 210

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In this review, we evaluated the overall changes to the intestinal flora alongside variations to the specific strains within the microbiota and established their association with PPI-related digestive disorders whilst detailing all possible mechanisms of action involved in this relationship (Figure 3)