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Regarding genotoxicity, in vitro work performed by Yu and colleagues using a laryngeal cancer cell line (HN30 and UMSCC10B) exposed to e-cigarette extract showed increased comet tail length and H2A.x (95), indicative of increased DNA damage, and in particular, double-stranded breaks

5 (2025): 957, [17] Empty Packs Survey: USA-CA Q2 2023, WSPM Group, August 2023, 3, 10, [18] Empty Packs Survey: USA-CA Q2 2023, WSPM Group, August 2023, 5, [19] Empty Packs Survey: USA-CA Q2 2023, WSPM Group, August 2023, 5, [20] Adam Hoffer, Cigarette Taxes and Cigarette Smuggling by State, 2022(Tax Foundation, November 26, 2024), [21] Shannon M