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J Agric Food Chem 33:11781181 Brunnemann KD, Genoble L, Hoffmann D (1987) Identification and analysis of a new tobacco-specific N-nitrosamine, 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanol

Food and Drug Administration (FDA) Commissioner and the Center for Tobacco Products (CTP) Director stated in 2017, Nicotine, though not benign, is not directly responsible for the tobacco-caused cancer, lung disease, and heart disease that kill hundreds of thousands of Americans each year