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Negative effects of alcohol 2 that contribute to a hangover include: Accumulation of toxic byproducts, including acetaldehyde Nutrient depletion Hormonal imbalances, including increased cortisol (a stress hormone) and lower serotonin (affecting your mood) Dehydration Inflammation Poor sleep quality When you drink, your liver works overtime to metabolize alcohol into acetaldehyde, a toxic byproduct that contributes to hangover symptoms, including headaches, nausea, and fatigue

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This was determined by taking the average cost of one 20-pack of cigarettes in each state and adjusting this based on the average consumption of 15 cigarettes per day