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The effect of 23 (HA08) was similar to that of brain-derived neurotrophic factor (BDNF) that is a known inducer of spine development ( Small Molecule Insulin-Regulated Aminopeptidase Inhibitors From In Silico Screening In 2008, Siew Chai and her group in Australia disclosed the first generation of drug-like small molecular weight inhibitors of IRAP ( in silico screening of a homology model of IRAP based on the crystal structure of LTA4H (Leukotriene-A4 hydrolase) was applied (Thunnissen et al., 2001)

10.1002/ajmg.b.30026