www.pubmed.gov glutathione Changes in levels of the antioxidant in brain and blood across the age span of healthy adults: A systematic review Glutathione and peroxisome redox homeostasis

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Introduction The first reports about a plant glutathione S-transferase enzyme (GST, EC 2.5.1.18) appeared in 1970, when it was revealed that a GST catalyzed the detoxification of the herbicide atrazine by its conjugation to the endogenous tripeptide glutathione (GSH, -L-glutamyl-L-cysteinyl-glycine) in sorghum and maize plants (Frear and Swanson, 1) and the nucleophilic GSH, thus tagging the xenobiotic for vacuolar sequestration (Martinoia et al., 1) (Bartling et al., Figure 1 (B) Nucleophilic addition reaction between cinnamic acid and GSH (Edwards and Dixon, (C) Reduction (detoxification) of fatty acid hydroperoxides to corresponding hydroxy derivatives by the peroxidase activity of GST as described by Bartling et al