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Long-term outcomes Do combinations provide sustained benefits beyond monotherapy over 1-2 year timeframes

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Solid-state structures, cellular assays and microsomal studies confirm that BCHep substitution mitigates reactive metabolite formation, validating aryl-fused BCHeps as true bioisosteric replacements for meta -substituted arenes and 2-naphthalenes

Although it counteracted DEX-induced spatial memory deficits, the results observed with SERT in healthy mice corroborate the report of a study by Siepmann et al [81] that showed that in healthy humans, SERT was not associated with cognitive deficits or improvements in cognition