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Post-translation modifications of ATXN3 include phosphorylation [130,131,132], ubiquitylation [133,134,135], and SUMOylation [136, 137]

In obese individuals, the expression and activity of aromatase in the adipose tissue are enhanced, thereby promoting the synthesis of peripheral estrogen and leading to elevated systemic estrogen levels ( Prolactin-secreting cells (prolactinocytes) are the main target of 17-estradiol (E2)

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The expression levels of seleno-GPxs can be increased either through transcriptional induction or by elevating bioavailable selenium which supports their translation [8, 20, 24,25,26,27]