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Clinical evidence for IGF-associated immunosuppression comes from reports of low tumor infiltrating lymphocytes (TILs) in high IGF-1R PCa bone metastases, and genomic aberrations in cancer patients with hyper-progressive disease post-ICB, including mutations in negative IGF regulator IGFBP2 and transcriptional upregulation of IGF-1, PI3K-AKT and ERK pathways 17,18

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109 OppenheimerJHoyteFCLPhipatanakulWSilverJHowarthPLugogoNL

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The Glutathione System in Parkinson's Disease and its Progression

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